Detection of phosphatidylserine with a modified polar head group in human keratinocytes exposed to the radical generator AAPH

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Detection of phosphatidylserine with a modified polar head group in human keratinocytes exposed to the radical generator AAPH.

Phosphatidylserine (PS) is preferentially located in the inner leaflet of the cell membrane, and translocation of PS oxidized in fatty acyl chains to the outside of membrane has been reported as signaling to macrophage receptors to clear apoptotic cells. It was recently shown that PS can be oxidized in serine moiety of polar head-group. In the present work, a targeted lipidomic approach was app...

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ژورنال

عنوان ژورنال: Archives of Biochemistry and Biophysics

سال: 2014

ISSN: 0003-9861

DOI: 10.1016/j.abb.2014.02.002